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ea0065oc5.3 | Adrenal and Cardiovascular | SFEBES2019

Common variants in the gene encoding corticosteroid binding globulin influence cortisol-responsive gene networks in human adipose tissue

Bankier Sean , Crawford Andrew , Wang Lingfei , Bjorkegren Johan , Andrew Ruth , Walker Brian R , Michoel Tom

A genome wide meta-analysis by the CORtisol NETwork (CORNET) consortium1 has identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with changes in morning plasma cortisol and predictive of cardiovascular disease (Crawford et al, Unpublished). SERPINA6 encodes Corticosteroid Binding Globin (CBG) which binds most cortisol in blood and influences delivery of cortisol to target tissues. We hypothesised th...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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